ZnuA

• Description: ABC transporter for zinc (binding protein, lipoprotein)
  
  

Gene name	znuA
Synonyms	ycdH
Essential	no
Product	ABC transporter for zinc (binding protein)
Function	zinc uptake
Gene expression levels in SubtiExpress: znuA
Interactions involving this protein in SubtInteract: ZnuA
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	35 kDa, 5.146
Gene length, protein length	957 bp, 319 aa
Immediate neighbours	ycdG, znuC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins

This gene is a member of the following regulons

Zur regulon

The gene

Basic information

• Locus tag: BSU02850

Phenotypes of a mutant

• • reduced genetic competence, can be rescued by the addition of excess zinc PubMed
  • reduced expression of the comFA-comFB-comFC-yvyF-flgM-yvyG-flgK-flgL operon PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial solute-binding protein 9 family (according to Swiss-Prot)

• Paralogous protein(s): MntA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: ZnuA-ZnuB-ZnuC PubMed

• Localization:
  • associated to the membrane (via ZnuB) PubMed
  • extracellular lipoprotein (signal peptide) PubMed

Database entries

• Structure: 2O1E

• UniProt: O34966

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: znuA-znuC-znuB PubMed

• Expression browser: znuA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by zinc starvation (Zur) PubMed

• Regulatory mechanism:
  • Zur: transcription repression in the presence of zinc PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: