PabB

• Description: para-aminobenzoate synthase (subunit A)
  
  

Gene name	pabB
Synonyms	pab
Essential	no
Product	para-aminobenzoate synthase (subunit A)
Function	biosynthesis of folate
Gene expression levels in SubtiExpress: pabB
Interactions involving this protein in SubtInteract: PabB
Metabolic function and regulation of this protein in SubtiPathways: pabB
MW, pI	53 kDa, 5.234
Gene length, protein length	1410 bp, 470 aa
Immediate neighbours	cysK, pabA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU00740

Database entries

• BsubCyc: BSU00740

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate (according to Swiss-Prot)

• Protein family: anthranilate synthase component I family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • PabA-PabB

• Localization:

Database entries

• BsubCyc: BSU00740

• Structure:

• UniProt: P28820

• KEGG entry: [3]

• E.C. number: 2.6.1.85

Expression and regulation

• Operon: pabB-pabA-pabC-sul-folB-folK-yazB-yacF-lysS PubMed

• Expression browser: pabB PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 129 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 381 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Antoine de Saizieu, Pierre Vankan, Cassandra Vockler, Adolphus P G M van Loon
The trp RNA-binding attenuation protein (TRAP) regulates the steady-state levels of transcripts of the Bacillus subtilis folate operon.
Microbiology (Reading): 1997, 143 ( Pt 3);979-989
[PubMed:9084182] [WorldCat.org] [DOI] (P p)