EfeO

• Description: lipoprotein, elemental iron uptake system (binding protein), high affinity uptake of ferric iron (Fe(III))
  
  

Gene name	ywbM
Synonyms	ipa-28d
Essential	no
Product	elemental iron uptake system (binding protein)
Function	elemental iron uptake
Gene expression levels in SubtiExpress: efeO
Interactions involving this protein in SubtInteract: EfeO
Metabolic function and regulation of this protein in SubtiPathways: EfeO
MW, pI	42 kDa, 4.712
Gene length, protein length	1155 bp, 385 aa
Immediate neighbours	efeB, efeU
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, acquisition of iron, iron metabolism, membrane proteins

This gene is a member of the following regulons

Fur regulon

The gene

Basic information

• Locus tag: BSU38270

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • binds ferric iron (Fe(III)) with strong selectivity PubMed

• Protein family: UPF0409 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • EfeO-EfeU-EfeB PubMed

• Localization:
  • membrane PubMed
  • extracytosolic lipoprotein PubMed

Database entries

• Structure:

• UniProt: P39596

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • efeU-efeO-efeB PubMed

• Expression browser: efeO PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced upon iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 1047 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 2113 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: