Glutamate metabolism

Proteins involved in glutamate metabolism

Transport systems

• Ammonium uptake: AmtB
• Glutamine uptake: GlnT, GlnQ-(GlnM-GlnP)-GlnH
• Glutamate uptake: YbeC, GltT

Metabolic enzymes

• Glutamine synthetase: GlnA
• Glutamate synthase: GltA, GltB
• Glutamate dehydrogenases: GudB, RocG

Regulators

• Key transcriptional regulators of nitrogen metabolism: GlnR, GltC, TnrA
• Additional transcriptional regulators: AhrC, RocR, CcpA, Fur
• Control of ammonium uptake: GlnK

Relevant SubtiWiki pages

• Biosynthesis/ acquisition of amino acids
• Utilization of amino acids
• TnrA regulon
• GlnR regulon
• GltC regulon
• Trigger enzymes

Additional websites

• transcriptome analysis of a rocG gudB mutant vs. wild type

Labs studying glutamate metabolism

• Fabian Commichau, Göttingen, Germany
• Susan Fisher, Boston
• Linc Sonenshein, Boston
• Jörg Stülke, Göttingen

Important publications

Important original publications

Anne Krog, Tonje Marita Bjerkan Heggeset, Trond Erling Ellingsen, Trygve Brautaset
Functional characterization of key enzymes involved in L-glutamate synthesis and degradation in the thermotolerant and methylotrophic bacterium Bacillus methanolicus.
Appl Environ Microbiol: 2013, 79(17);5321-8
[PubMed:23811508] [WorldCat.org] [DOI] (I p)