PtsH
- Description: General (non sugar-specific) component of the sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.
| Gene name | ptsH |
| Synonyms | |
| Essential | write here |
| Product | histidine-containing phosphocarrier protein of the PTS |
| Function | mediates carbon catabolite repression (CCR) |
| MW, pI | 9,1 kDa, 4.58 |
| Gene length, protein length | 264 bp, 88 amino acids |
| Immediate neighbours | ptsG, ptsI |
| Gene sequence (+200bp) | Protein sequence |
| Genetic context File:GenE context.gif | |
Contents
The gene
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry:[2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Protein HPr N(pi)-phospho-L-histidine + protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L-histidine
- Protein family: HPr family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: HPr Domain (2–88)
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions: GapA-PtsH, PtsH-MtlR, PtsH-LicR, PtsH-LevR, PtsH-ManR, YesS-PtsH (HPr-His-P), PtsH-CcpA PubMed, PtsH-RbsR, HprK-PtsH
- Localization: Cytoplasm
Database entries
- Structure: NCBI, (complex of L. Casei HprK with B. Subtilis HPr) NCBI, (complex of L. Casei HprK with B. Subtilis HPr-Ser-P) NCBI
- Swiss prot entry: [3]
- KEGG entry: [4]
- E.C. number: [5]
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
Labs working on this gene/protein
Your additional remarks
References
- Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
- Macek B, Mijakovic I, Olsen JV (2007) The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis. Mol Cell Proteomics 6(4): 697-707. PubMed
- Mahr K, Esteban CD, Hillen W (2002) Cross communication between components of carbon catabolite repression of Lactobacillus casei and Bacillus megaterium. J Mol Microbiol Biotechnol. 4(5): 489-94. PubMed
- Juy M, Penin F, Favier A, Galinier A (2003) J Mol Biol. 332(4): 767-76. PubMed
