LpdV

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  • Description: 2-oxoisovalerate dehydrogenase (E3 subunit, dihydrolipoamide dehydrogenase)

Gene name lpdV
Synonyms yqiV, bkd
Essential no
Product 2-oxoisovalerate dehydrogenase
(E3 subunit, dihydrolipoamide dehydrogenase)
Function utilization of branched-chain keto acids
MW, pI 48 kDa, 4.893
Gene length, protein length 1371 bp, 457 aa
Immediate neighbours bkdAA, buk
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
LpdV context.gif
This image was kindly provided by SubtiList




The gene

Basic information

  • Locus tag: BSU24060

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH (according to Swiss-Prot)
  • Protein family: class-I pyridine nucleotide-disulfide oxidoreductase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed