lip

lip
168

extracellular lipase

locus
BSU_02700
Molecular weight
22.64 kDa
pI
10.06
Protein length
212 aaSequenceBlast
Gene length
639 bpSequenceBlast
function
lipid degradation
product
extracellular lipase
essential
no
synonyms
lip, lipA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1075 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
292,205  292,843
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The protein
Catalyzed reaction/ biological activity
triacylglycerol + H2O --> diacylglycerol + fatty acid + H+ (according to UniProt)
Protein family
[wiki|AB hydrolase superfamily] (according to UniPort)
Structure
[PDB|2QXT] [pubmed|18053819]
[PDB|1I6W]
[AF|P37957]
Paralogous protein(s)
[protein|2053E27BE6837D2B167960C9B07C8B7B7BBABE25|lipB]
Expression and Regulation
Operons
genes
[gene|0DB03F47C7AA45BF52653B1C0B2C5025960C53D7|lip]
description
[Pubmed|21815947]
regulation
repressed during vegetative growth ([protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]) [Pubmed|18840696]
regulatory mechanism
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|18840696], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
additional information
the amount of the mRNA is substantially decreased upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
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[gene|0DB03F47C7AA45BF52653B1C0B2C5025960C53D7|lip]

2024-07-25 03:53:36

Bzhu

54

3cf2372641cdd597cec3eebd8d473a87204a1a59

0CE168007FE995D4A6D70A31C5457D3085DAD42A

Biological materials
Mutant
BKE02700 ([gene|0DB03F47C7AA45BF52653B1C0B2C5025960C53D7|lip]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02700 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAATATCCTCCTTTTTTT,  downstream forward: _UP4_TAATGAAAAACAAAACCTTG
BKK02700 ([gene|0DB03F47C7AA45BF52653B1C0B2C5025960C53D7|lip]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02700 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAATATCCTCCTTTTTTT,  downstream forward: _UP4_TAATGAAAAACAAAACCTTG
References
22996591,22267088,23404771,21477088,22246996,23639749,21815947,24402332,15812018,12523966,18721749,12218047,16342303,12951259,11583117,11491291,18383241,19180538,8396026,19883129,18840696,18053819,24827611,12077437,25122499,25495458,26147762,26488405,27003415,27239434,27696241,28050632,18053819,30286107,31553080,32183336,34134054,37989487

0DB03F47C7AA45BF52653B1C0B2C5025960C53D7

Page visits: 3885

Time of last update: 2024-09-04 08:46:29

Author of last update: Jstuelk