coaBC
168
Coenzyme A biosynthesis bifunctional protein CoaBC; putative phosphopantothenoylcysteine synthetase/decarboxylase
locus
BSU_15700
Molecular weight
43.82 kDa
pI
6.01
function
biosynthesis of coenzyme A
product
putative phosphopantothenoylcysteine synthetase/decarboxylase
essential
yes
ec
4.1.1.36
synonyms
yloI
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0452 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,642,851 1,644,071
Phenotypes of a mutant
essential [Pubmed|28189581]
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The protein
Catalyzed reaction/ biological activity
H+ + N-[(R)-4-phosphopantothenoyl]-L-cysteine --> CO2 + D-pantetheine 4'-phosphate (according to UniProt)
(R)-4'-phosphopantothenate + CTP + L-cysteine --> CMP + diphosphate + H+ + N-[(R)-4-phosphopantothenoyl]-L-cysteine (according to UniProt)
Protein family
N-terminal part: HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily (single member, according to UniProt)
C-terminal part: PPC synthetase family (single member, according to UniProt)
Structure
[PDB|6TGV] (from Mycobacterium smegmatis, 38.8% identity) [pubmed|33420031]
[PDB|5INT] (from ''Bacillus anthracis'', 60% identity in 52% C-terminal fragment)
[AF|O35033]
Expression and Regulation
Operons
genes
[gene|A57D2C1536F3E93CD687C28C59FF297355CAB303|yloC]-[gene|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|remA]-[gene|1BC994DE60A7BB35DEDD7154581A396D29AA94A7|gmk]-[gene|921933B6B893083F151AABDEDCBC65F2E55677BE|yloH]-[gene|2B67C63442F28F6BCBA3BA6DE4B563C73E8DF16C|coaBC]-[gene|AF5ADDA2A98EC18BB72A81AA0336E639C0D1F430|priA]-[gene|3D41FB608DB70B9482312A1BBCCDBDA7FB713AFA|defA]-[gene|06971E9AAB033E2878914A76645F99E97CE8A90A|fmt]-[gene|1370D8783450D538C71E3DE8EA5B37DFEE073FF0|yloM]-[gene|5DEBD84E5937DB8B7F29C729FAA0076DF86A5451|yloN]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-B372 (yloI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1371 NBRP B. subtilis, Japan]
References
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Time of last update: 2024-05-23 03:31:23
Author of last update: Jstuelk