med
168
lipoprotein, positive regulator of [gene|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK], stimulates [protein|511E71BB1981758857854C8E9BF657287CE60C11|kinD]-dependent phosphorylation of [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]
locus
BSU_11300
Molecular weight
35.16 kDa
pI
4.6
function
regulation of competence
product
positive regulator of [gene|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]
essential
no
synonyms
med, yjaW
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1744 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,206,629 1,207,582
Phenotypes of a mutant
impaired biofilm formation [Pubmed|21622736]
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The protein
Catalyzed reaction/ biological activity
stimulates [protein|511E71BB1981758857854C8E9BF657287CE60C11|kinD]-dependent phosphorylation of [protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A] [Pubmed|21622736]
Protein family
BMP lipoprotein family (with [protein|19BA45BD691BBA4B23C4741C63DB729AA5D30FDA|nupN], according to UniProt)
Structure
[PDB|2HQB] (from B. halodurans, 49% identity) [pubmed|17636568]
[AF|O32436]
[wiki|Localization]
cell surface [Pubmed|12036071]
Expression and Regulation
Operons
genes
[gene|D08B0A131374D2949ABC3EF8D6117C6BC6D94FE5|yjaV]-[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
description
[pubmed|22383849]
sigma factors
[protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE]: sigma factor, [Pubmed|15699190], in [regulon|protein:3CB24D493B3282278B7DC61CE3C793DFA815F9E2|sigE regulon]
genes
[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
description
[Pubmed|9335269]
regulation
repressed under conditions that trigger sporulation ([wiki|Spo0A]) [Pubmed|14651647]
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9335269], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
genes
[gene|2BF1CA62F5B8B54A25B70721D39B5BD38C0203EB|yjaU]-[gene|D08B0A131374D2949ABC3EF8D6117C6BC6D94FE5|yjaV]-[gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]-[gene|8914DE1312FD3C28E7D451A034814D92D1312B10|comZ]
description
[Pubmed|22383849]
Biological materials
Mutant
BKE11300 ([gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE11300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGTCATGTTCAACTCCTT, downstream forward: _UP4_AACGAGTAATGGAGTGACGT
BKK11300 ([gene|4DAB7847EA3848A34432C80124464543FA3DCA0F|med]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK11300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAGTCATGTTCAACTCCTT, downstream forward: _UP4_AACGAGTAATGGAGTGACGT
References
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Time of last update: 2024-10-04 06:34:24
Author of last update: Melvin.boenninger