panG
168
ketopantoate reductase
locus
BSU_14440
Molecular weight
33.42 kDa
pI
6.14
function
biosynthesis of coenzyme A
product
ketopantoate reductase
essential
no
ec
1.1.1.-
synonyms
ykpB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1893 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,514,052 1,514,963
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The protein
Catalyzed reaction/ biological activity
2-dehydropantoate + H+ + NADPH --> (R)-pantoate + NADP+ [https://www.biorxiv.org/content/10.1101/2024.04.17.589903v1.full.pdf bioRxiv]
Protein family
ketopantoate reductase family (with [protein|0F153803781C9AC8321FB14F926B645C45E53B00|panE], according to UniProt)
Structure
[PDB|3HN2] (from Geobacter metallireducens, 26% identity)
[AF|O31717]
Expression and Regulation
Operons
genes
[gene|2F79DB15D359A127C2D833CC0465E18E1725F539|ykpA]-[gene|60264E4BE76F5995A8317294D05FC27F8B34E09D|panG]
description
[pubmed|22383849]
Biological materials
Mutant
MGNA-B353 (ykpB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1352 NBRP B. subtilis, Japan]
BKE14440 ([gene|60264E4BE76F5995A8317294D05FC27F8B34E09D|panG]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTGTGATCTCCTTTCA, downstream forward: _UP4_TAAAAAAAGGAGGCGGAAAA
BKK14440 ([gene|60264E4BE76F5995A8317294D05FC27F8B34E09D|panG]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14440 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTGTGATCTCCTTTCA, downstream forward: _UP4_TAAAAAAAGGAGGCGGAAAA
GP3347 ([gene|60264E4BE76F5995A8317294D05FC27F8B34E09D|panG]::lox72 trpC2), available in [wiki|Jörg Stülke]'s lab
GP3383 (Δ[gene|60264E4BE76F5995A8317294D05FC27F8B34E09D|panG]::neo trpC2), available in [wiki|Jörg Stülke]'s lab
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Time of last update: 2024-11-29 20:45:37
Author of last update: Jstuelk