ftsA
168
cell division protein, membrane anchor for [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ]
locus
BSU_15280
Molecular weight
47.94 kDa
pI
5.09
function
formation of Z-ring
product
[wiki|cell division] protein, member of the [wiki|divisome]
essential
no
synonyms
ftsA, spoIIN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0849 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,596,474 1,597,796
Phenotypes of a mutant
cells become elongated [Pubmed|24218584]
the ''[gene|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA]'' mutation is synthetically lethal with a ''[gene|DB09F1C36257F511A84A083967A25A9D46744D14|sepF]'' mutation [Pubmed|24218584]
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The protein
Catalyzed reaction/ biological activity
required for septum recruitment of [protein|DF77B46666595E86081C5345C91E08F86DF9FAEE|sftA] [pubmed|29439991]
Protein family
[wiki|FtsA/MreB family] (according to UniProt)
Structure
[PDB|3WQT] (from Staphylococcus aureus, 31% identity) [pubmed|24746687]
[AF|P28264]
[wiki|Localization]
during vegetative growth: uniform [protein|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA]-[protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] rings around the leading edge of the invaginating medial septum to orchestrate [wiki|cell division] ([protein|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA] is proximal to the membrane and tethers [protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ]) [pubmed|34018921]
at the onset of sporulation: [protein|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA]-[protein|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ] filaments are assembled only on the mother cell side of the invaginating polar septum, this depends on [protein|7C8DFE00A2B2B30CC8BEB35055D92CC2E4128F3A|spoIIE] [pubmed|34018921]
septal at the cell membrane (35% of the molecules) [Pubmed|29439991,20566861]
cytoplasma (65% of the molecules) [pubmed|29439991]
septal localization depends on the proton motive force [Pubmed|20566861]
Expression and Regulation
Operons
genes
[gene|672EA84D7725BE21F649DF30A11EB4E0EDFC3925|ftsA]-[gene|41872E2EF00C79918DD077F2EF78F37E24FEB110|ftsZ]
description
[Pubmed|1569582]
regulation
activated by [protein|search|WalR] [Pubmed|10878122]
regulatory mechanism
[protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]: activation, in [regulon|protein:7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1569582], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|1569582], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
additional information
half-life of the ''[wiki|ftsZ]'' mRNA: 2.2 min [Pubmed|26110430]
Biological materials
Mutant
1A787 ( ''ftsA''::''cat''), [Pubmed|8071208], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A787&Search=1A787 BGSC]
References
Reviews
Original Publications
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Time of last update: 2024-11-13 09:40:49
Author of last update: Jstuelk