lytB
168
modifier protein of major autolysin [protein|6A21293823151C6980BF52B31A4B249A8440F2E1|lytC]
locus
BSU_35630
Molecular weight
76.55 kDa
pI
9.84
function
autolysis
product
modifier protein of major autolysin [protein|6A21293823151C6980BF52B31A4B249A8440F2E1|lytC]
essential
no
synonyms
lytB, cwbA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2385 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,660,648 → 3,662,765
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The protein
Structure
[PDB|4RWR] (B. anthracis [protein|AAC4BF6FA80115AB90D2B161C1D5383625953616|spoIID], corresponds to aa 414 ... 702) [pubmed|27226615]
[AF|Q02113]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|497C9654DC7514FF738D18E1F083299C43003A4C|lytA]-[gene|E1F9922DF7273040F84E5AC207A9F4CAFB85DC75|lytB]-[gene|6A21293823151C6980BF52B31A4B249A8440F2E1|lytC]
description
[Pubmed|1357079]
expression
expression is heterogeneous [pubmed|35171018]
regulatory mechanism
[protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR]: repression, in [regulon|protein:5A6FBAE6553343092862CB79E150F934978C32A9|sinR regulon]
[protein|7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb]: repression, [Pubmed|16306698], in [regulon|protein:7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb regulon]
[protein|920F91E748EE079FF864011D9052B073567C41E4|slrR]: repression, (in complex with [protein|5A6FBAE6553343092862CB79E150F934978C32A9|sinR]) [Pubmed|20351052], in [regulon|protein:920F91E748EE079FF864011D9052B073567C41E4|slrR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|1357079], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|1357079], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
Biological materials
Mutant
1A789 ( ''lytB''::''kan''), [Pubmed|1588906], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A789&Search=1A789 BGSC]
BKE35630 (Δ[gene|E1F9922DF7273040F84E5AC207A9F4CAFB85DC75|lytB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE35630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAATTTCAGGTTCCTCCC, downstream forward: _UP4_TGATTATTTTAGGATATAAC
BKK35630 (Δ[gene|E1F9922DF7273040F84E5AC207A9F4CAFB85DC75|lytB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK35630 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAATTTCAGGTTCCTCCC, downstream forward: _UP4_TGATTATTTTAGGATATAAC
References
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Time of last update: 2024-07-02 06:48:22
Author of last update: Melvin.boenninger