sigA

sigA
168

[wiki|RNA polymerase] major [wiki|sigma factor] SigA

locus
BSU_25200
Molecular weight
42.80 kDa
pI
4.63
Protein length
371 aaSequenceBlast
Gene length
1116 bpSequenceBlast
function
transcription
product
[wiki|RNA polymerase] major [wiki|sigma factor] SigA
essential
yes
synonyms
sigA, rpoD, crsA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0568 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,600,214  2,601,329
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Protein family
[wiki|Sigma-70 factor family] (according to UniProt)
Structure
[PDB|3IYD] ([wiki|RNA polymerase] from ''E. coli'', 69% identity) [Pubmed|19903881]
[AF|P06224]
Modification
phosphorylated on Arg-365 [Pubmed|31221751]
[wiki|Localization]
cytoplasm [Pubmed|25313396]
Expression and Regulation
Operons
genes
[gene|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]
description
[Pubmed|3919021]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|3298998], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|3127379], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
[protein|7024E4162A6D827069F882FDEACA696EBC05DD40|sigD]: sigma factor, [Pubmed|3919021], in [regulon|protein:7024E4162A6D827069F882FDEACA696EBC05DD40|sigD regulon]
additional information
An [wiki|antisense RNA] is predicted for [gene|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA] [PubMed|20525796]
Open in new tab

[gene|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]

2024-10-05 17:49:48

Bzhu

112

a44c2f03a365c290be3c4cf068b0b7648c95b50f

35FB4314AECBA079829FB92ECC99EE838CC81E44

genes
[gene|398924959D6C82918617C4B050F72D5E78EE12E9|yqxD]-[gene|F7B53E8AC92DAD15544C6208C2A5B41BABA73D6D|dnaG]-[gene|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]
description
[Pubmed|3298998]
regulation
enzymatic activity is inhibited by (p)ppGpp during the 'stringent response
regulatory mechanism
[protein|2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A]: repression, [Pubmed|14651647], in [regulon|protein:2C54FE2ADC82FF414D732018C90649D477A925AD|spo0A regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|3298998], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH]: sigma factor, [Pubmed|3127379], in [regulon|protein:DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|sigH regulon]
additional information
An [wiki|ncRNA|antisense RNA] is predicted for [gene|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA] [PubMed|20525796]
Open in new tab

[gene|398924959D6C82918617C4B050F72D5E78EE12E9|yqxD]→[gene|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]

2024-10-09 03:21:57

TPed

136

345BE3439F4414F1DA2FD49B273925B808601AB7

E9F2D1769ACB2AF65C67D8854D4F58BC49368B55

labs
[wiki|Charles Moran], Emory University, NC, USA [http://www.microbiology.emory.edu/moran_c.html homepage]
References
Reviews
22210308,24308327
Original Publications
36815589,12486038,10556308,8107087,14762002,7918363,8071196,7630711,9185571,9287022,14679239,14976210,19735077,2997585,9658000,3127379,10438769,11535782,7599136,9144176,19680289,20525796,22333917,20935043,20817769,23875654,25112476,26582911,19903881,27977677,28539362,28648455,29363854,31221751,32127479,34530448,34898263,35241653,37350110,37728605,38348908

360F48D576DE950DF79C1A2677B7A35A8D8CC30C

Page visits: 13918

Time of last update: 2024-11-09 00:49:15

Author of last update: Jstuelk