kre
168
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK] repressor, stimulates degradation of the [gene|search|comK ]mRNA
locus
BSU_14020
Molecular weight
17.75 kDa
pI
10.17
function
control of [protein|search|ComK ]accumulation and of bistable competence gene expression
product
[protein|search|ComK ]repressor
essential
no
synonyms
kre, ykyB
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms
This gene is a member of the following regulons
Gene
Coordinates
1,474,560 1,475,024
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The protein
Catalyzed reaction/ biological activity
stimulates [protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK] mRNA degradation [Pubmed|26110430]
controls stability of several mRNAs (see [wiki|Kre regulon]) [Pubmed|26110430]
Structure
[AF|P42430]
[wiki|Localization]
cytoplasm [Pubmed|26110430]
Expression and Regulation
Operons
genes
[gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]
description
[Pubmed|8169223]
regulation
repressed in competent cells ([wiki|ComK]) [Pubmed|26110430]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: repression, [Pubmed|26110430], in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
Biological materials
Mutant
MGNA-A764 (ykyB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/764 NBRP B. subtilis, Japan]
PG479 (ykyB::erm), available in [wiki|Leendert Hamoen]'s and [wiki|Jörg Stülke]'s labs [Pubmed|26110430]
GP2533 ([gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]::''erm''), available in [wiki|Jörg Stülke]'s lab
BKE14020 ([gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATTTCTCTCCTTTGCT, downstream forward: _UP4_TAAAATAAAAACAGCCGTGC
BKK14020 ([gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATTTCTCTCCTTTGCT, downstream forward: _UP4_TAAAATAAAAACAGCCGTGC
References
Reviews
Original Publications
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Time of last update: 2024-11-13 22:35:04
Author of last update: Jstuelk