Difference between revisions of "Phosphorelay"
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==The kinases== | ==The kinases== | ||
| − | * [[KinA]] (controlled by [[Sda]], [[KipI]], and [[KipA]]) | + | * [[KinA]] (controlled by [[Sda]], [[SivA]], [[BslA]], [[KipI]], and [[KipA]]) |
* [[KinB]] (controlled by [[Sda]], [[KbaA]], and [[KapB]]) | * [[KinB]] (controlled by [[Sda]], [[KbaA]], and [[KapB]]) | ||
* [[KinC]] | * [[KinC]] | ||
* [[KinD]] | * [[KinD]] | ||
* [[KinE]] | * [[KinE]] | ||
| + | |||
| + | ==Proteins controlliing the activity of the kinases== | ||
| + | * [[BslA]] | ||
| + | * [[KapB]] | ||
| + | * [[KbaA]] | ||
| + | * [[KipA]] | ||
| + | * [[KipI]] | ||
| + | * [[Sda]] | ||
| + | * [[SivA]] | ||
| + | * [[SivC]] | ||
==The phosphotransferases== | ==The phosphotransferases== | ||
Revision as of 11:53, 1 February 2013
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see Table to the right |
Contents
The phosphorelay is a complex variation of a two-component regulatory system. It includes phosphotransferases that transfer the phosphoryl group from the sensor kinases to the ultimate target. The sporulation initiation phosphorelay is the paradigm of this class of signal transduction systems.
The kinases
- KinA (controlled by Sda, SivA, BslA, KipI, and KipA)
- KinB (controlled by Sda, KbaA, and KapB)
- KinC
- KinD
- KinE
Proteins controlliing the activity of the kinases
The phosphotransferases
The ultimate target
Phosphatases controlling the phosphorelay (and peptides that modulate their activity)
- Spo0E: dephosphorylation of Spo0A
- YisI: dephosphorylation of Spo0A
- YnzD: dephosphorylation of Spo0A
- RapA, PhrA: dephosphorylation of Spo0F
- RapB: dephosphorylation of Spo0F
- RapE, PhrE: dephosphorylation of Spo0F
- RapH: dephosphorylation of Spo0F
A mathematical model
Reviews
Additional reviews: PubMed
Imke G de Jong, Jan-Willem Veening, Oscar P Kuipers
Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation.
J Bacteriol: 2010, 192(8);2053-67
[PubMed:20154131]
[WorldCat.org]
[DOI]
(I p)
Ruth E Silversmith
Auxiliary phosphatases in two-component signal transduction.
Curr Opin Microbiol: 2010, 13(2);177-83
[PubMed:20133180]
[WorldCat.org]
[DOI]
(I p)
Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980]
[WorldCat.org]
[DOI]
(I p)
Daelynn R Buelow, Tracy L Raivio
Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases.
Mol Microbiol: 2010, 75(3);547-66
[PubMed:19943903]
[WorldCat.org]
[DOI]
(I p)
Keith Stephenson, James A Hoch
Evolution of signalling in the sporulation phosphorelay.
Mol Microbiol: 2002, 46(2);297-304
[PubMed:12406209]
[WorldCat.org]
[DOI]
(P p)
M Perego, J A Brannigan
Pentapeptide regulation of aspartyl-phosphate phosphatases.
Peptides: 2001, 22(10);1541-7
[PubMed:11587783]
[WorldCat.org]
[DOI]
(P p)
J A Hoch, K I Varughese
Keeping signals straight in phosphorelay signal transduction.
J Bacteriol: 2001, 183(17);4941-9
[PubMed:11489844]
[WorldCat.org]
[DOI]
(P p)
J A Hoch
Two-component and phosphorelay signal transduction.
Curr Opin Microbiol: 2000, 3(2);165-70
[PubMed:10745001]
[WorldCat.org]
[DOI]
(P p)
M Perego
Kinase-phosphatase competition regulates Bacillus subtilis development.
Trends Microbiol: 1998, 6(9);366-70
[PubMed:9778730]
[WorldCat.org]
[DOI]
(P p)
M Perego, P Glaser, J A Hoch
Aspartyl-phosphate phosphatases deactivate the response regulator components of the sporulation signal transduction system in Bacillus subtilis.
Mol Microbiol: 1996, 19(6);1151-7
[PubMed:8730857]
[WorldCat.org]
[DOI]
(P p)
J A Hoch
The phosphorelay signal transduction pathway in the initiation of Bacillus subtilis sporulation.
J Cell Biochem: 1993, 51(1);55-61
[PubMed:8432743]
[WorldCat.org]
[DOI]
(P p)
K Trach, D Burbulys, M Strauch, J J Wu, N Dhillon, R Jonas, C Hanstein, P Kallio, M Perego, T Bird
Control of the initiation of sporulation in Bacillus subtilis by a phosphorelay.
Res Microbiol: 1991, 142(7-8);815-23
[PubMed:1664534]
[WorldCat.org]
[DOI]
(P p)
Important original publications
Additional original publications: PubMed
Anna L McLoon, Ilana Kolodkin-Gal, Shmuel M Rubinstein, Roberto Kolter, Richard Losick
Spatial regulation of histidine kinases governing biofilm formation in Bacillus subtilis.
J Bacteriol: 2011, 193(3);679-85
[PubMed:21097618]
[WorldCat.org]
[DOI]
(I p)
