Difference between revisions of "Phosphorelay"
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* 3.4.7. [[Phosphorelay]] | * 3.4.7. [[Phosphorelay]] | ||
* 3.4.8. [[Quorum sensing]] | * 3.4.8. [[Quorum sensing]] | ||
| + | * 3.4.9. [[Other regulators]] | ||
|Related= | |Related= | ||
| − | + | see Table to the right | |
|}} | |}} | ||
__TOC__ | __TOC__ | ||
| − | <br><br><br> | + | <br><br><br><br><br> |
The phosphorelay is a complex variation of a [[two-component systems|two-component regulatory system]]. It includes phosphotransferases that transfer the phosphoryl group from the sensor kinases to the ultimate target. The sporulation initiation phosphorelay is the paradigm of this class of signal transduction systems. | The phosphorelay is a complex variation of a [[two-component systems|two-component regulatory system]]. It includes phosphotransferases that transfer the phosphoryl group from the sensor kinases to the ultimate target. The sporulation initiation phosphorelay is the paradigm of this class of signal transduction systems. | ||
==The kinases== | ==The kinases== | ||
| − | * [[KinA]] (controlled by [[Sda]], [[KipI]], and [[KipA]]) | + | * [[KinA]] (controlled by [[Sda]], [[SivA]], [[BslA]], [[KipI]], and [[KipA]]) |
* [[KinB]] (controlled by [[Sda]], [[KbaA]], and [[KapB]]) | * [[KinB]] (controlled by [[Sda]], [[KbaA]], and [[KapB]]) | ||
* [[KinC]] | * [[KinC]] | ||
* [[KinD]] | * [[KinD]] | ||
* [[KinE]] | * [[KinE]] | ||
| + | |||
| + | ==Proteins controlliing the activity of the kinases== | ||
| + | * [[BslA]] | ||
| + | * [[KapB]] | ||
| + | * [[KbaA]] | ||
| + | * [[KipA]] | ||
| + | * [[KipI]] | ||
| + | * [[Sda]] | ||
| + | * [[SivA]] | ||
| + | * [[SivC]] | ||
==The phosphotransferases== | ==The phosphotransferases== | ||
| Line 57: | Line 68: | ||
* [[RapE]], [[PhrE]]: dephosphorylation of [[Spo0F]] | * [[RapE]], [[PhrE]]: dephosphorylation of [[Spo0F]] | ||
* [[RapH]]: dephosphorylation of [[Spo0F]] | * [[RapH]]: dephosphorylation of [[Spo0F]] | ||
| + | * [[RapP]]: dephosphorylation of [[Spo0F]] {{PubMed|23524609}} | ||
| + | |||
| + | == Other protein controlling the activity of the phosphorelay == | ||
| + | * the [[YmcA]]- [[YlbF]]-[[YaaT]] complex stimulates phosphotransfer to [[Spo0A]] {{PubMed|23490197}} | ||
==A mathematical model== | ==A mathematical model== | ||
| − | <pubmed> 20238180 </pubmed> | + | <pubmed> 20238180 25341802 27122155</pubmed> |
| + | |||
==Reviews== | ==Reviews== | ||
| − | <pubmed>8730857 11587783 9778730 1664534 12406209 11489844 10745001 8432743 19995980 19943903 20133180 20154131 </pubmed> | + | <pubmed>8730857 11587783 9778730 1664534 12406209 11489844 10745001 8432743 19995980 19943903 20133180 20154131 21435030 27501460 26941227 32156829,32156813 |
| + | </pubmed> | ||
| + | |||
| + | ==Important original publications== | ||
| + | <pubmed> 21097618 23169620,22146301 26165942 27216630,30212463,35012345</pubmed> | ||
| + | |||
| + | =Back to [[categories]]= | ||
Latest revision as of 09:46, 21 January 2022
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| Related categories | |
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see Table to the right |
Contents
- 1 The kinases
- 2 Proteins controlliing the activity of the kinases
- 3 The phosphotransferases
- 4 The ultimate target
- 5 Phosphatases controlling the phosphorelay (and peptides that modulate their activity)
- 6 Other protein controlling the activity of the phosphorelay
- 7 A mathematical model
- 8 Reviews
- 9 Important original publications
- 10 Back to categories
The phosphorelay is a complex variation of a two-component regulatory system. It includes phosphotransferases that transfer the phosphoryl group from the sensor kinases to the ultimate target. The sporulation initiation phosphorelay is the paradigm of this class of signal transduction systems.
The kinases
- KinA (controlled by Sda, SivA, BslA, KipI, and KipA)
- KinB (controlled by Sda, KbaA, and KapB)
- KinC
- KinD
- KinE
Proteins controlliing the activity of the kinases
The phosphotransferases
The ultimate target
Phosphatases controlling the phosphorelay (and peptides that modulate their activity)
- Spo0E: dephosphorylation of Spo0A
- YisI: dephosphorylation of Spo0A
- YnzD: dephosphorylation of Spo0A
- RapA, PhrA: dephosphorylation of Spo0F
- RapB: dephosphorylation of Spo0F
- RapE, PhrE: dephosphorylation of Spo0F
- RapH: dephosphorylation of Spo0F
- RapP: dephosphorylation of Spo0F PubMed
Other protein controlling the activity of the phosphorelay
A mathematical model
Heiko Babel, Ilka B Bischofs
Molecular and cellular factors control signal transduction via switchable allosteric modulator proteins (SAMPs).
BMC Syst Biol: 2016, 10;35
[PubMed:27122155]
[WorldCat.org]
[DOI]
(I e)
Adaoha E C Ihekwaba, Ivan Mura, Gary C Barker
Computational modelling and analysis of the molecular network regulating sporulation initiation in Bacillus subtilis.
BMC Syst Biol: 2014, 8;119
[PubMed:25341802]
[WorldCat.org]
[DOI]
(I e)
Sara Jabbari, John T Heap, John R King
Mathematical modelling of the sporulation-initiation network in Bacillus subtilis revealing the dual role of the putative quorum-sensing signal molecule PhrA.
Bull Math Biol: 2011, 73(1);181-211
[PubMed:20238180]
[WorldCat.org]
[DOI]
(I p)
Reviews
Important original publications
